Table 1. Phenotypes of mice with conditional knockout and control genotypes* .
Genotype | Urine albumin (mg/24 hrs) | Nephritis |
B6.Podocin/cre,Pdss2loxP/loxP | 32.89 +/− 7.64 (28)** | 1.80 +/− 0.29 (26) |
B6.PEPCK/cre, Pdss2loxP/loxP | 0.18 +/− 0.05 (18) | 0.05 +/− 0.05 (20) |
B6.LysM/cre, Pdss2loxP/loxP | 0.12 +/− 0.01 (6) | 0.33 +/− 0.08 (6) |
B6.Alb/cre,Pdss2loxP/loxP | 0.13 +/− 0.03 (6) | 0.17 +/− 0.15 (6) |
B6.Pdss2kd/kd | 21.17 +/− 5.41 (6) | 2.11 +/− 0.40 (9) |
B6. Pdss2loxP/loxP | 0.24 +/− 0.07 (7) | 0.73 +/− 0.22 (11) |
B6 | 0.12 +/− 0.01 (8) | 0.58 +/− 0.18 (12) |
*: All mice at least 120 days old.
**: Mean +/− SEM; N is shown in parentheses.