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. 2004 Jan 21;24(3):652–660. doi: 10.1523/JNEUROSCI.4220-03.2004

Figure 8.

Figure 8.

Blockade of mGluR II/III receptors with CPPG in vivo decreases the extent of post-odor synaptic depression and adaptation of odor responses. A, Example of an odor response recorded in aPCX layer during the initial portion of the 50 sec conditioning odor. B, Response to the 2 sec test odor given 50 sec after the cessation of the conditioning odor in the control animal shown in A. C, LOT shock-evoked response slopes in aPCX were depressed after 50 sec of odor exposure. CPPG infusion significantly decreased the extent of synaptic depression. Asterisks signify significant difference between drug conditions (p < 0.05). D, Fifty seconds of odor presentation resulted in adaptation to a 2 sec odor given 50 sec after the conditioning odor. CPPG infusion significantly decreased the extent of odor adaptation. Asterisks signify significant difference between drug conditions (p < 0.05). Bars indicate duration of odor exposure.