Table 2a.
Weighted means (WM 0–12 h) for active treatment comparisons
| Tio vs. S100 | Tio vs. S50 | S100 vs. S50 | |
|---|---|---|---|
| FEV1‡ | −0.04 (−0.09, 0.01) | 0.05 (−0.001, 0.09) | 0.09 (0.04, 0.13)* |
| MMEF‡ | −0.06 (−0.11, −0.01)† | 0.01 (−0.05, 0.06) | 0.07 (0.02, 0.12)* |
| sGaw§ | 0.96 (0.89, 1.04) | 1.10 (1.02, 1.19)* | 1.14 (1.06, 1.23)* |
| RV‡ | −0.01 (−0.14, 0.12) | −0.08 (−0.21, 0.04) | −0.08 (−0.20, 0.05) |
| R5‡ | −0.01 (−0.03, 0.02) | −0.03 (−0.05, −0.01)* | −0.02 (−0.05, −0.001)* |
| R15‡ | 0.004 (−0.01, 0.02) | −0.01 (−0.02, 0.003) | −0.02 (−0.03, −0.001)* |
| R20‡ | 0.01 (0.00, 0.02) | −0.001 (−0.01, 0.01) | −0.01 (−0.02, −0.001)* |
| R25‡ | 0.01 (−0.01, 0.02) | −0.01 (−0.02, 0.004) | −0.02 (−0.03, −0.003)* |
| R35‡ | 0.02 (0.01, 0.03)† | 0.004 (−0.01, 0.02) | −0.01 (−0.02, −0.001)* |
| RF‡ | −0.79 (−1.99, 0.41) | −1.64 (−2.83, −0.45)* | −0.85 (−2.04, 0.34) |
| X5‡ | −0.01 (−0.04, 0.03) | 0.01 (−0.02, 0.04) | 0.01 (−0.02, 0.05) |
Tio, Tiotropium bromide 18 µg; S100, salmeterol 100 µg; S50, salmeterol 50 µg. Data are
‡
mean difference (95% confidence intervals) or
§
geometric mean (95% confidence intervals).
*
Superiority of Tio over S100, Tio over S50 or S100 over S50.
†
Superiority of S100 over T. Data for TLC, FRC and IC are not shown as no significant differences seen.
FEV1, Forced expiratory volume in 1 s; MMEF, maximum mid-expiratory flow; sGaw, specific airway conductance; RV, residual volume; R, resistance; X, reactance.