Table 2b.
Weighted means (WM 12–24 h) for active treatment comparisons
| Tio vs. S100 | Tio vs. S50 | S100 vs. S50 | |
|---|---|---|---|
| FEV1† | 0.01 (−0.05, 0.06) | 0.12 (0.06, 0.17)* | 0.11 (0.06, 0.17)* |
| MMEF† | −0.02 (−0.07, 0.03) | 0.05 (−0.001, 0.09) | 0.07 (0.02, 0.11)* |
| sGaw‡ | 1.12 (1.02, 1.23)* | 1.23 (1.12, 1.34)* | 1.10 (1.00, 1.20)* |
| RV† | −0.04 (−0.20, 0.12) | −0.17 (−0.33, −0.02)* | −0.13 (−0.29, 0.02) |
| R5† | −0.06 (−0.09, −0.02)* | −0.09 (−0.12, −0.05)* | −0.03 (−0.06, 0.01) |
| R15† | −0.03 (−0.05, −0.01)* | −0.04 (−0.07, −0.02)* | −0.01 (−0.04, 0.01) |
| R20† | −0.02 (−0.03, 0.001) | −0.02 (−0.04, −0.01)* | −0.01 (−0.03, 0.01) |
| R25† | −0.02 (−0.03, 0.002) | −0.03 (−0.05, −0.02)* | −0.02 (−0.03, 0.00) |
| R35† | −0.01 (−0.02, 0.01) | −0.02 (−0.03, −0.002)* | −0.01 (−0.02, 0.01) |
| RF† | −2.30 (−3.83, −0.77)* | −3.64 (−5.16, −2.11)* | −1.33 (−2.86, 0.19) |
| X5† | 0.03 (−0.01, 0.06) | 0.06 (0.02, 0.09)* | 0.03 (−0.003, 0.06) |
Tio, Tiotropium bromide 18 µg; S100, salmeterol 100 µg; S50, salmeterol 50 µg. Data are
†
mean difference (95% confidence intervals) or
‡
geometric mean (95% confidence intervals).
*
Superiority of Tio over S100, Tio over S50 or S100 over S50. Data for static lung volumes are not shown as no significant differences seen. FEV1, Forced expiratory volume in 1 s; MMEF, maximum mid-expiratory flow; sGaw, specific airway conductance; RV, residual volume; R, resistance; X, reactance.