Table 1.
Effects of Danshen extract on pharmacokinetic parameters of theophylline in healthy volunteers
| PK parameter | Baseline (n = 12) | Danshen (n = 12) | Geometric LS mean ratio, % | 90% CI | P-value |
|---|---|---|---|---|---|
| t1/2 (h) | 6.66 ± 0.81 | 6.69 ± 1.02 | 94.78 | (84.57, 106.22) | – |
| Tmax (h) | 1.60 ± 0.22 | 1.30 ± 0.45 | – | – | 0.285* |
| Cmax (mg l−1) | 1 882.11 ± 154.2 | 2 134.21 ± 404.6 | 110.94 | (101.42, 121.36) | – |
| CL/F (l h−1) | 4.37 ± 0.28 | 4.47 ± 0.85 | 96.90 | (88.82, 105.72) | – |
| AUC0–∞ (mg l−1) | 22 969.6 ± 1470.05 | 23 031.11 ± 4 457.24 | 103.42 | (94.82, 112.80) | – |
*
Wilcoxon signed rank test.