Table 1.

Perhexiline and other drug therapy in six CYP2D6 EM and two CYP2D6 PM patients

Patient	Rac-perhexiline maleate	Other drugs
EM1	100 mg a.m., 100 mg p.m.	Aspirin, clopidogrel, perindopril, metoprolol, simvastatin, frusemide, metformin, glicazide, isosorbide dinitrate
EM2	150 mg a.m.	Aspirin, insulin (s.c.), morphine (s.c.), verapamil, pantoprazole, prednisolone, spironolactone, venlafaxine, paracetamol, frusemide, isosorbide mononitrate, ipratropium (inhalation), salbutamol (inhalation)
EM3	100 mg a.m.	Frusemide, paroxetine, pantoprazole, theophylline, aspirin, spironolactone, salmeterol (inhalation), fluticasone (inhalation), prednisolone
EM4	50 mg a.m.	Diltiazem, amitriptyline, prednisolone, glimepiride, frusemide, tiotropium (inhalation), salmeterol (inhalation), fluticasone (inhalation), ramipril, aspirin, isosorbide mononitrate, theophylline
EM5	100 mg a.m., 100 mg p.m.	Clopidogrel, ramipril, pravastatin, isosorbide mononitrate, metoclopramide (i.v.)
EM6	100 mg a.m., 100 mg p.m.	Glyceryl trinitrate, aspirin, irbesartan, pantoprazole, clopidogrel, isosorbide dinitrate, pravastatin
PM1	50 and 100 mg, alternate weeks	Omeprazole, isosorbide mononitrate, trandolapril, clopidogrel, risedronate, allopurinol, frusemide
PM2	100 mg weekly	Aspirin, diltiazem, atorvastatin, gliclazide, thyroxine, indapamide, irbesartan, amitriptyline, isosorbide dinitrate, clopidogrel

Administration was oral unless otherwise indicated. EM, extensive metabolizer; PM, poor metabolizer; s.c., subcutaneous; i.v., intravenous.