Table 3.

Renal excretion of (+)- and (−)-PHX at steady-state in five EM patients

Patient	Dose recovered (%) (+)-PHX	(−)-PHX:	CLGF (ml h−1 kg−1) (+)-PHX	(+)-PHX	CLR (ml h−1 kg−1)	(−)-PHX:	CLR (−)-PHX CLR (+)-PHX
EM1	0.75	0.55	0.22	0.16	2.40	2.30	0.96
EM2	2.28	1.73	0.36	0.26	1.58	1.53	0.97
EM3	0.48	0.37	0.74	0.54	0.16	0.16	1.00
EM4	0.57	0.51	0.44	0.33	0.83	0.83	1.00
EM5	0.09	0.08	0.51	0.38	0.20	0.21	1.05
Mean	0.84	0.65	0.45	0.33	1.03	1.01	1.00
(95% CI)	(−0.21, 1.88)	(−0.14, 1.43)	(0.21, 0.69)	(0.16, 0.51)	(−0.15, 2.22)	(−0.13, 2.14)	(0.95, 1.04)

PHX, Perhexiline. EM, extensive metabolizer.