Table 3.
P450 phenotyping of liver grafts. Drug-metabolizing capacity of grafts showing normal function (n = 14) was compared with P450 activities of grafts HH-069 and HH-074
| Enzyme activity (pmol mg−1 min−1) | |||
|---|---|---|---|
| P450 | Liver grafts (n = 14) | HH-069 | HH-074 |
| CYP1A2 | 286.3 ± 373.66 | 421.0 | 1107.1 |
| CYP2A6 | 718.8 ± 532.48 | 716.2 | 1354.1 |
| CYP2B6 | 52.7 ± 43.00 | 538.3 | 215.1 |
| CYP2C9 | 271.2 ± 89.70 | blq | 572.5 |
| CYP2C19 | 29.5 ± 17.25 | 32.8 | blq |
| CYP2D6 | 442.2 ± 116.64 | 604.8 | 1069.7 |
| CYP2E1 | 1105.4 ± 335.03 | 905.2 | 2135.5 |
| CYP3A4/5 | 892.5 ± 645.96 | 1013.9 | 1197.8 |
blq, below the limit of quantification.