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Scatter plots. (A) Correlation between the log sparteine metabolic ratio (MR) and the steady-state nortriptyline/(E)-10-hydroxynortriptyline ratio in 21 patients treated with 10–100 mg amitriptyline (AT) daily. (B) Correlation between the log sparteine MR and the steady-state amitriptyline/(E)-10-hydroxyamitriptyline ratio in 21 patients treated with 10–100 mg AT) daily. (2 functional CYP2D6 alleles, (
); 1 functional CYP2D6 allele, (○); 0 functional CYP2D6 allele, (•))
