Table 2a.

Kinetic parameters of arginine in human plasma after 1 week of oral supplementation with either citrulline or arginine^‡

Compound	Dose (mg)	Cmax (µmol l−1)	Tmax (h)	Cmin (µmol l−1)	AUC (µmol h l−1)
Citrulline	750 bid	54 ± 5	2.3 ± 0.7	19 ± 4	271 ± 38
Citrulline	1500 bid	79 ± 8*	1.6 ± 0.3	21 ± 4	421 ± 65*
Citrulline	3000 bid	149 ± 42*†	1.4 ± 0.1	45 ± 5*†	898 ± 67*†
Arginine SR	1600 bid	49 ± 6	3.7 ± 1.3§	19 ± 4	289 ± 50
Arginine lR	1000 tid	84 ± 9	0.7 ± 0.1	10 ± 3	283 ± 51

^*P < 0.01 vs. arginine sustained-release (SR).

^†P < 0.01 vs. arginine immediate-release (IR).

^§P = 0.03 vs. arginine IR.

^‡Kinetic parameters are calculated for baseline-placebo corrected data. Data are given as mean ± SEM. bid, twice daily.