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Mean plasma concentrations of rosiglitazone and N-desmethylrosiglitazone in 32 healthy Whites after a single 4-mg oral dose of rosiglitazone in relation to the SLCO1B1 c.521T→C single nucleotide polymorphism. For clarity, only mean values are presented. Insets depict the same data on a semilogarithmic scale. ○, Subjects with the SLCO1B1 c.521TT genotype (n = 16); •, subjects with the c.521TC genotype (n = 12); ▴, subjects with the c.521CC genotype (n = 4)
