Table 2.
Invasive procedures (N = 29) successfully treated with rFVIIa as first-line therapy (3 non-evaluablea episodes and 2 failuresb not included) (data from Poon (2004))
| Bolus injections | Median (range) | Continuous infusion | Median (range) |
|---|---|---|---|
| Major surgery: all 3 episodesc | Major Surgery: all 3 episodesd | ||
| Dosage (μg/kg per injection) | 92(80–92) | Initial bolus dosage (μg/kg) | 49(28–70) |
| Doses used (N) | 14(4–33) | CI dosage (μg/kg/h) | 5(5–30) |
| Duration of treatment (h) | 47(11–141) | Duration of treatment (h) | 282(225–336) |
| Minor surgery: all 20 epidsodese | Minor surgery: all 3 episodesf | ||
| Dosage (μg/kg per injection) | 109(74–150) | Initial bolus dosage (μg/kg) | 88(72–110) |
| Doses used (N) | 3(1–19) | CI dosage (μg/kg/h) | 12(9–20) |
| Duration of treatment (h) | 7(0.1–152) | Duration of treatment (h) | 67(60–267) |
| Minor surgery: 9 dental extraction | |||
| Dosage (μg/kg per injection) | 100(78–134) | ||
| Doses used (N) | 3(1–19) | ||
| Duration of treatment (h) | 6(0.1–152) |
Nonevaluables: two major (pyelonephrectomy, skin grafting) and 1 minor (central catheter insertion).
Failures: persistent oozing after endoscopic uterine myometomy; recurrent hematuria following ureteric stent removal.
Major by bolus injection: laparotomy, laparoscopic bilateral oophorectomy, hysterectomy.
Major by CI: colostomy, colostomy revision, intestinal resection.
Minor by bolus injection: Nine dental extractions, 4 other dental procedures, 2 colonoscopy/polypectomy, one each of cystoscopy/ureteric stent insertion, hernia repair, tracheostomy, knee injection, otolaryngological cryosurgery.
Minor by CI: central cathetre removal, colonoscopy/polypectomy, cystoscopy/ureteric stent insertion.