Figure 2.

The BErgamo NEphrologic DIabetes Complications Trial (BENEDICT) is a multicenter double-blind, randomized study designed to assess whether the angiotensin converting enzyme inhibitor trandolapril and the non-dihydropyridine calcium-channel blocker verapamil, alone or in combination, prevent microalbuminuria in subjects with hypertension, type 2 diabetes mellitus, and normal urinary albumin excretion. The Kaplan-Meier curves show the percentages of subjects with microalbuminuria during treatment with trandolapril/verapamil or placebo. The difference between the two groups adjusted for pre-specified baseline covariates was significant (p = 0.01) according to the accelerated failure (A.F.)-time model.

Abbreviations: DBP, diastolic blood pressure; SBP, systolic blood pressure.