Table 2.
Pharmacokinetic interaction between oral trandolapril or verapamil SR and other agents when administered concomitantly (only clinically relevant interactions are cited)
| Effects of verapamil-SR on pharmacokinetics of | |
|---|---|
| Carbamazapine | Increases the plasma concentration of carbamazapin |
| Cyclosporine | Increases the serum concentration of cyclosporine |
| Digoxin | Increases the serum concentration of digoxin |
| Ethanol | Verapamil decreases the elimination of ethanol |
| Metoprololo/propanolol | Verapamil decreases the clearance |
| Quinidine | Increases the serum concentration of quinidine |
| Effects of trandolapril on | |
| Lithium | Trandolapril (ACE inhibitors) increase serum concentration of lithium |
| Effects of other agents on verapamil SR pharmacokinetics | |
| Cimetidine | Increase in verapamil clearance is possible |
| Erythromycin | Increases plasma level of verapamil due to inhibition of CYP3A4 inhibition |
| Grapefruit juice | Increases plasma concentration of verapamil |
| Phenobarbitone | Increases verapamil clearance |
| Rifampicine | Decreases verapamil bioavailability due to CYP3A4 induction |
| Ritonavir | Increases plasma level of verapamil due to inhibition of CYP3A4 inhibition |
| Effects of other agents on trandolapril pharmacokinetics | |
| Antacids | Decreases the bioavailability of trandolapril |