Adverse experience leading to dose reduction in the VALIANT trial. Adapted with permission from table 3 in Pfeffer MA, McMurray JJV, Velazquez EJ, et al. 2003. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both [Erratum in N Engl J Med, 2004. 350:203]. N Engl J Med, 349:1893–906. Copyright © Massachusetts Medical Society. All rights reserved.