Table 1.
Comparison of the cytotoxicity of cisplatin, LA-12 and satraplatin (JM-216) against cisplatin-resistant tumor cell lines. Values of IC50 were calculated for 24 hour exposure time (adapted from Turánek et al. Anticancer Drugs. 2004,15:537-543).
| Cancer cell line | IC50 (μM ) | ||
|---|---|---|---|
| Cisplatin | LA-12 | Satraplatin | |
| K562 | >80 | 3 | 63 |
| KG-1 | 48 | 2 | 63 |
| ML-2 | >80 | 1 | 56 |
| B16 | >80 | 6 | >80 |
| HT-29N | >80 | 12 | >80 |
| HT-29 | 50 | 8 | 70 |
| HCT116 | >80 | 9 | >80 |
| A427 | 63 | 6 | 13 |
| HBL100 | 63 | 6 | >80 |
| MCF-7 | 71 | 8 | 70 |
| CPRL23/CTR | >80 | 25 | 56 |
| A2780 | 7 | 4 | 63 |
| A2780cis40 | 40 | 3 | 40 |
| A2790cis90 | >80 | 7 | 63 |