Table 2.
Population pharmacokinetic parameter estimates for SDx and CQ in 83 children aged 6–60 months
| Model parameters* | SDx estimate (RSE%) | IIV (RSE%) | CQ estimate (RSE%) | IIV (RSE%) |
|---|---|---|---|---|
| VC (l kg−1) |  |
– | 31.8 (20) | 0.57 (67) |
| Slope | 1.53 (18) | 0.47 (33) | – | – |
| CL (l h−1) | 0.023 (5.3) | 0.33 (35) | 2.84 (5.4) | 0.3 (35) |
| CLD2 (l h−1) | 0.13 (15) | – | 3.29 (11) | – |
| Vp (l kg−1) | 1.6 (16) | – | 230 (7.8) | – |
| ka (h−1) | 0.30 (24) | – | 0.14 (13) | – |
| Lag time (h) | 0.29 (14) | – | Not estimated | – |
| Additive error | 2.6 (100) | – | 0.5 (6.3) | – |
| Proportional error | 0.27 (12) | – | Not estimated | – |
*
CL, apparent clearance; CLD2, apparent intercompartmental clearance values; IIV, interindividual variability; ka, absorption rate constant; Lag-time, absorption lag-time; RSE, relative standard error in percent; Slope, factor relating the volume of distribution to normalized body weight (BW); VC, apparent central volume of distribution; Vp, apparent volume of peripheral compartment.