Table 3.

Descriptive statistics of individual post hoc secondary parameter estimates for SDx by dose group

	Dose 250 mg, age 6–24 months			Dose 500 mg, age 24–60 months
Parameters‡	Mean	SD	Min–max	Mean	SD	Min–max
Cmax† (μg ml−1)	130	24	99–227	171	32	85–249
tmax (h)	5.7	0.60	3.6–6.9	7.0	0.68	4.8–8.0
α-HL (h)	3.1	0.48	1.5–3.9	4.2	0.49	3.0–5.0
β-HL (h)	113	37	51–217	98	32	18–177
AUC(0,336 h)† (μg ml−1 h)	12 500	3250	6 280–21 900	16 900	4690	2 840–27 500
AUC(0,24 h)† (μg ml−1 h)	2 310	305	1 830–3 330	3 240	560	1 680–4 510

^†Unpaired t-test for difference between low and high dose groups were all significant at P < 0.00005.

^‡α-HL, initial disposition half-life; β-HL, terminal elimination half-life; C_max, maximum blood concentration attained; t_max, the time to maximum blood concentration.