Table 2.

Pharmacokinetic parameters of voriconazole and N-oxide metabolite

	Arithmetic mean (SD)
Pharmacokinetic parameter	Day 4	Day 60	% Ratio (90% CI)*
Voriconazole
AUCτ (ng h ml−1)	14 893 (8 949)	20 986 (10 393)	145.84 (132.13, 160.97)
Cmax (ng ml−1)	2 637 (921)	3 016 (1 041)	114.30 (103.05, 126.77)
Tmax (h)†	1 (0.5, 2)	1 (1, 6)	–‡
N-oxide metabolite
AUCτ (ng h ml−1)	39 556 (6 563)	36 002 (5 779)	91.07 (88.15, 94.08)
Cmax (ng ml−1)	3 921 (556)	3 401 (500)	86.70 (83.57, 89.95)
Tmax (h)†	3 (0.5, 6)	3 (0, 6)	–‡

^*Represents adjusted geometric mean ratio of day 60/4-values.

^†Median (range).

^‡Not analysed. SD, Standard deviation; CI, confidence interval.