Table 3.
Pharmacokinetic parameters of ethinyl oestradiol and norethindrone
| Arithmetic mean (SD) | |||
|---|---|---|---|
| Pharmacokinetic parameter | Day 32 | Day 60 | % Ratio (90% CI)* |
| Ethinyl oestradiol | |||
| AUCτ (pg h ml−1) | 1116 (510) | 1748 (639) | 160.68 (149.81, 172.35) |
| Cmax (pg ml−1) | 125 (41) | 168 (51) | 135.99 (127.67, 144.85) |
| Tmax (h)† | 2 (0.5, 2) | 2 (1, 2) | –‡ |
| Norethindrone | |||
| AUCτ (ng h ml−1) | 122 (47) | 182 (49) | 153.39 (143.80, 163.62) |
| Cmax (ng ml−1) | 18 (5) | 21 (5) | 114.91 (103.05, 128.14) |
| Tmax (h)† | 1 (1, 2) | 1 (0.5, 1) | –‡ |
*
Represents adjusted geometric mean ratio of day 60/32 values.
†
Median (range).
‡
Not analysed. SD, Standard deviation; CI, confidence interval.