Table 3.

Results from simulations of several once-daily dosing regimens

	Percentage of patients
Dosing regimen	350 mg	7.5 mg kg−1	8.5 mg kg−1	10 mg kg−1	11 mg kg−1	12 mg kg−1
Within AUC range (80–125 mg l h−1)	37.9	21.7	44.2	72.1	76.9	69.4
Outside AUC range (80–125 mg l h−1)	62.1	78.3	55.8	27.9	23.2	30.6
Below AUC 80 mg l h−1	36.6	78.1	55.0	22.2	10.3	4.4
Above AUC 125 mg l h−1	25.5	0.2	0.8	5.7	12.9	26.2
Below 1 mg l−1 at 24 h	100	100	100	100	100	100
Below 0.3 mg l−1 at 24 h	97.2	100	99.8	99.7	99.6	99.6
Within Cmax range (24–38 mg l−1)	29.8	17.3	55.8	91.6	92.5	80.2
Below Cmax of 24 mg l−1	39.0	82.7	44.2	7.1	1.3	0.4
Above Cmax of 38 mg l−1	31.2	0	0	1.3	6.2	19.4