Table 2.
Population pharmacokinetic parameters (and relative standard error in percentage) of nelfinavir and M8 from basic and final models
| Basic model estimate (RSE%) | Final model estimate (RSE%) | |
|---|---|---|
| Structural model | ||
| ka (h−1) | 0.16 (25) | 0.17 (27) |
| tlag (h−1) | 0.83 (6) | 0.82 (6) |
| V/F (l) | 176 (12) | 191 (15) |
| CLT/F (l h−1) | 51.3 (10) | 52 (10) |
 (h−1) |
0.26 (40) | 0.39 (35) |
| kem (h−1) | 1.56 (38) | 1.76 (30) |
 |
/ | 0.98 (49) |
| Statistical model | ||
| ωKa (%) | 102 (37) | 99 (42) |
 (%) |
50 (24) | 49 (26) |
 (%) |
65 (30) | 59 (29) |
| σNFV (%) | 31 (15) | 32 (15) |
| σM8 (%) | 48 (22) | 49 (22) |
| r σNFV − σM8 | / | 0.37 (40) |