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. Author manuscript; available in PMC: 2009 Feb 28.
Published in final edited form as: Auton Neurosci. 2008 Feb 29;138(1-2):9–23. doi: 10.1016/j.autneu.2007.11.001

Figure 1. The Summary of Antidormic Mechanisms of SCS-Induced Vasodilation in Limbs and Feet.

Figure 1

The diagram summarizes the antidromic mechanisms that SCS activates TRPV1 containing sensory neurons. The neural information is transmitted from the site of stimulation in the spinal segments to the nerve endings in the peripheral tissues and results in the production and release of vasodilators, including CGRP. CGRP, the most powerful vasodilator, then binds its receptors in endothelial cells and their activation leads to the production and subsequent release of NO to vascular smooth muscle cells, which results in relaxation.