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Schematic on how different p38 isoforms regulate myogenin induction through distinct target genes. Three p38 isoforms can regulate myogenin expression through both common target genes (e.g., E2F2) and unique isoform-specific target genes (e.g., cyclin D3 and WISP1). Unlike E2F2 and cyclin D3, WISP1 participates in myogenin regulation in an autocrine manner. G0, G1, G2, S, and M denote different phases of the cell cycle.
