Table 2.
TNF-α gene polymorphism in promoter region in cured SARS patients, health care workers and individual control
| SNP site | SARS (%) | Health Care Workers (%) | Individual Control (%) | OR1 (95%CI) | OR2 (95%CI) |
| -1031 | |||||
| Genotype | |||||
| TT | 45(63.4) | 25(64.1) | 61(67.8) | - | - |
| CT | 23(32.4) | 13(33.3) | 27(30.0) | 0.98(0.43–2.27) | 1.12(0.59–2.27) |
| CC | 3(4.2) | 1(2.6) | 2 (2.2) | 1.67(0.17–16.88) | 2.03(0.33–12.68) |
| Allele | |||||
| T | 79.6 | 80.8 | 74.5 | ||
| C | 20.4 | 19.2 | 25.5 | ||
| -863 | |||||
| Genotype | |||||
| CC | 55(73.3) | 29(72.5) | 64(70.3) | - | - |
| AC | 19(25.3) | 11(27.5) | 27(29.7) | 0.91(0.38–2.17) | 0.82(0.41–1.63) |
| AA | 1(1.3) | 0 | 0 | 0.98(0.94–1.07)& | 2.16(1.78–2.63)& |
| Allele | |||||
| C | 86.0 | 86.3 | 85.2 | ||
| A | 14.0 | 13.7 | 14.8 | ||
| -857 | |||||
| Genotype | |||||
| CC | 56(74.7) | 31(77.5) | 66(72.5) | - | - |
| CT | 19(25.3) | 8(20.0) | 25(27.5) | 1.32(0.52–3.35) | 0.90(0.45–1.79) |
| TT | 0 | 1(2.5) | 0 | 1.03(0.97–1.1)$ | - |
| Allele | |||||
| C | 131(87.3) | 70(87.5) | 157(86.3) | ||
| T | 19(12.7) | 10(12.5) | 25(13.7) | ||
| -572 | |||||
| Genotype | |||||
| AA | 73(97.3) | 40(97.6) | 90(97.8) | - | - |
| AC | 2(2.7) | 1(2.4) | 2(2.2) | 1.10(0.10–12.46) | 1.23(0.17–8.97) |
| Allele | |||||
| A | 98.7 | 98.8 | 98.9 | ||
| C | 1.3 | 1.2 | 1.1 | ||
| -308 | |||||
| Genotype | |||||
| GG | 67(89.3) | 39(95.1) | 88(95.7) | - | - |
| AG | 7(9.1) | 2(4.9) | 4(4.3) | 2.04(0.40–10.30) | 2.30(0.65–8.18) |
| AA | 1(1.3) | 0 | 0 | 0.98(0.96–1.01)& | 2.31(1.93–2.77)& |
| Allele | |||||
| G | 94.0 | 97.6 | 100.0 | ||
| A | 6.0 | 2.4 | 0.0 | ||
| -238 | |||||
| Genotype | |||||
| GG | 65(86.7) | 39(95.1) | 84(91.3) | - | - |
| AG | 10(13.3) | 2(4.9) | 8(8.7) | 3.00(0.63–14.41) | 1.62(0.60–4.32) |
| Allele | |||||
| G | 93.3 | 97.6 | 95.7 | ||
| A | 6.7 | 2.4 | 4.3 | ||
| -204 | |||||
| Genotype | |||||
| TT | 75(100) | 41(100.0) | 87(94.6) | - | - |
| CT | 0(0.0) | 0 | 5(5.4) | - | 0.95(0.90–0.99)$ |
| Allele | |||||
| T | 100.0 | 100.0 | 97.3 | ||
| C | 0.0 | 0.0 | 2.7 | ||
| -163 | |||||
| Genotype | |||||
| GG | 74(98.7) | 41(100.0) | 87(94.6) | - | - |
| CG | 1(1.3) | 0 | 5 (5.4) | 0.98(0.96–1.01)& | 0.24(0.03–2.06) |
| Allele | |||||
| G | 99.3 | 100.0 | 97.3 | ||
| C | 0.7 | 0.0 | 2.7 |
Note: OR1 was calculated by comparing SARS with HCW;
OR2 was calculated by comparing SARS with individual control;
&: Odds ratio replaced with SARS group; $: Odds ratio replaced with control