Table 6.

TNF-α gene polymorphisms and the occurrence of interstitial lung fibrosis in SARS patients

SNP site	Interstitial lung fibrosis(%)	Non-interstitial lung fibrosis(%)	OR* (95%C.I.)	P
-1031
Genotype
TT	14(70)	12(57.1)
CT	6(30)	8(38.1)	0.64(0.17–2.38)	0.51
CC	0	1(4.8)	1.08(0.93–1.27)‡	0.48
Allele
T	85.00	76.19
C	15.00	23.81
-863
Genotype
CC	17(77.3)	16(72.7)
AC	5(22.7)	6(27.3)	0.78(0.20–3.08)	0.73
Allele
C	88.64	38
A	11.36	13.64
-857
Genotype
CC	15(68.8)	17(77.3)
CT	7(31.8)	5(22.7)	1.59(0.42–6.07)	0.50
Allele
C	84.09	88.64
T	15.91	11.36
-572
Genotype
AA	21(95.5)	22(100)
AC	1(4.5)	0	0.96(0.87–1.05)&	0.50
Allele
A	97.73	100.00
C	2.27	0.00
-308
Genotype
GG	21(95.5)	18(81.8)
AG	1(4.5)	4(18.2)	0.21(0.02–2.10)	0.17
Allele
G	97.73	90.9
A	2.27	9.1
-238
Genotype
GG	20(90.9)	18(81.8)
AG	2(9.1)	4(18.2)	0.45(0.07–2.76)	0.33
Allele
G	95.45	90.9
A	4.55	9.1

Note:*:OR was calculated using non-interstitial lung fibrosis as control.

&: Odds ratio replaced with interstitial lung fibrosis group;

‡: Odds ratio replaced with non-interstitial lung fibrosis group