Table 1.
Transcriptome analysis of inflammatory cytokines in esophageal mucosa from patients with non-erosive reflux disease (NERD)
| Probe ID | NERD | Normal | Ratio | Gene Title |
|---|---|---|---|---|
| 204470_at | 343.4 | 21.3 | 19.70 | chemokine (C-X-C motif) ligand 2 |
| 205476_at | 1877.3 | 217.9 | 14.93 | chemokine (C-C motif) ligand 20 |
| 207850_at | 1036.9 | 85.2 | 12.13 | chemokine (C-X-C motif) ligand 3 |
| 209774_x_at | 2321.4 | 273.5 | 10.56 | chemokine (C-X-C motif) ligand 2 |
| 211338_at | 18.6 | 5.7 | 4.29 | interferon, alpha 2 /// interferon, alpha 2 |
| 206508_at | 191.5 | 48.7 | 3.73 | tumor necrosis factor (ligand) superfamily, member 7 |
| 210118_s_at | 2570.1 | 555.8 | 3.48 | interleukin 1, alpha |
| 1557908_at | 97.7 | 39.1 | 2.83 | toll-interleukin 1 receptor (TIR) |
| 243977_at | 315.6 | 147.3 | 2.64 | interleukin 6 (interferon, beta 2) |
| 231779_at | 2584.4 | 768.0 | 2.30 | interleukin-1 receptor-associated kinase 2 |
| 202859_x_at | 348.8 | 135.7 | 2.14 | interleukin 8 |
| 221404_at | 1641.2 | 866.7 | 2.00 | interleukin 1 family, member 6 (epsilon) |
| 208771_s_at | 13123.1 | 8115.0 | 1.87 | leukotriene A4 hydrolase |
| 206295_at | 4809.5 | 2367.4 | 1.87 | interleukin 18 (interferon-gamma-inducing factor) |
| 233011_at | 5088.5 | 2337.0 | 1.74 | annexin A1 |
| 207008_at | 927.1 | 515.6 | 1.74 | interleukin 8 receptor, beta |
| 207072_at | 196.1 | 118.2 | 1.74 | interleukin 18 receptor accessory protein |
| 209499_x_at | 81.9 | 57.2 | 1.74 | tumor necrosis factor (ligand) member 13 |
| 203140_at | 3313.6 | 2193.9 | 1.62 | B-cell CLL/lymphoma 6 (zinc finger protein 51) |
| 205291_at | 536.3 | 444.7 | 1.62 | interleukin 2 receptor, beta |
| 202688_at | 3034.4 | 1392.6 | 1.62 | tumor necrosis factor (ligand) superfamily, member 10 |
| 207817_at | 16.7 | 15.9 | 1.62 | interferon, omega 1 |
| 200759_x_at | 2230.3 | 1321.0 | 1.52 | nuclear factor (erythroid-derived 2)-like 1 |
| 205185_at | 46702.0 | 30629.6 | 1.52 | serine protease inhibitor, Kazal type 5 |
| 219403_s_at | 2089.6 | 1591.4 | 1.52 | heparanase |
| 222484_s_at | 5301.6 | 3222.6 | 1.52 | chemokine (C-X-C motif) ligand 14 |
Biopsy specimens were taken from the mucosa at 5 mm above the esophagogastric junction. The GeneChip of human genome U133 Plus 2.0 array (Affymetrix), which contained 54675 probes selected from the UniGene database, was used to analyze gene expression.
There were detected 844 probes that showed a more than 1.5-fold upregulation in expression between normal control (n = 3) and NERD patients (n = 3)
Upregulated genes related to cytokines in NERD patients are shown in this table.