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. Author manuscript; available in PMC: 2008 Apr 10.
Published in final edited form as: Future Oncol. 2007 Apr;3(2):191–199. doi: 10.2217/14796694.3.2.191

Figure 2. USP7 preferentially deubiquitinates Hdm2.

Figure 2

Relative to p53, USP7 has a higher affinity for Hdm2, thus USP7 preferentially deubiquitinates Hdm2, preventing Hdm2 from inducing its own degradation due to autoubiquitination. Subsequently, Hdm2 ubiquitinates p53, which is degraded by the proteasome. An inhibitor of USP7 is predicted to promote the degradation of Hdm2 and therefore abrogate the degradation of p53 by the ubiquitin proteosome system.

ub: Ubiquitin; USP: Ubiquitin-specific protease.