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. 2008 Apr 16;2(4):e226. doi: 10.1371/journal.pntd.0000226

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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C57BL/6 mice were immunized three times at two week intervals with DNA plasmids coding for ten Phlebotomus papatasi salivary proteins, SGH and CTL DNA in the right ear. Two weeks later the left ear was challenged intradermally with 0.5 pairs of SGH. The DTH response was assessed using Δ ear thickness (ear thickness of experimental groups subtracted from the mean ear thickness of naïve mice) 48 hours after injection with 0.5 pairs of SGH. Bars represent the mean Δ ear thickness for 15 mice per group ± the SEM. Asterisks indicate statistical differences (p<0.05) compared to CTL DNA-immunized mice.