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. Author manuscript; available in PMC: 2008 Apr 10.
Published in final edited form as: Nature. 2000 Jun 15;405(6788):757–763. doi: 10.1038/35015500

Figure 2.

Figure 2

Microinjection of xTsg mRNA leads to ventralization of the embryo. a, Control embryo (left) and embryo with xTsg mRNA microinjected into each animal cell at the eight-cell stage (500 pg total; right), leading to the reduction of dorso-anterior structures. b-e, In situ analysis of late gastrulae microinjected with xTsg mRNA (500 pg per blastomere). Injected embryos (right) and uninjected controls (left) in dorsal view. b, Sox2; c, BMP-4; d, MyoD; e, Shh. The changes in gene expression are characteristic of ventralization in Xenopus3.