Table 1.
Associations between SNPs located in coding and regulatory regions in TLRs and associated intracellular signaling molecules and measles-specific immune responses
| Gene | SNP ID | Location | Function | Genotype | N* | Median response | P- value# | Q- value† |
|---|---|---|---|---|---|---|---|---|
| Ab (IU/L) | ||||||||
| MyD88 | Rs6853 | 3′UTR | - | AA/AG/GG | 149/38/3 | 1430/1583/272 | 0.001 | 0.33 |
| TLR3 | Rs3775291 | Ex4 + 601C > T | Phe412Leu | GG/GA/AA | 106/67/17 | 1602/1025/2133 | 0.02 | 0.46 |
| TLR3 | Rs5743305 | −976T > A | - | AA/AT/TT | 36/93/59 | 1412/1063/1670 | 0.004 | 0.35 |
| IL-4 (pg/mL) | ||||||||
| TLR4 | Rs4986790 | Ex4 + 636A > G | Gly299Asp | AA/AG/GG | 169/21/0 | 11/23/- | 0.02 | 0.44 |
| TLR4 | Rs4986791 | Ex4 + 936C > T | Ile399Thr | CC/CT/TT | 169/21/0 | 10/23/- | 0.009 | 0.35 |
| IL-10 (pg/mL) | ||||||||
| MD2 | Rs11466004 | Ex5 + 85C > T | Ser157Pro | CC/CT/TT | 177/6/0 | 31/4/- | 0.03 | 0.46 |
| IL-12p40 (pg/mL) | ||||||||
| TLR2 | Rs3804100 | Ex3 + 1366T > C | Ser450Ser | TT/TC/CC | 159/29/2 | 8/5/133 | 0.01 | 0.35 |
| IFN-γ (pg/mL) | ||||||||
| TLR3 | Rs3775296 | 5′UTR | - | GG/GT/TT | 134/50/6 | 44/112/101 | 0.03 | 0.46 |
| TLR6 | Rs5743818 | Ex1 + 756G > T | Ala644Ala | TT/TG/GG | 96/76/18 | 51/78/38 | 0.02 | 0.46 |
| TLR5 | Rs5744174 | Ex4 + 936C > T | Leu616Phe | CC/CT/TT | 42/87/61 | 72/82/37 | 0.002 | 0.33 |
| LPA (SI) | ||||||||
| TLR3 | Rs5743305 | −976T > A | - | AA/AT/TT | 36/93/59 | 3.7/3.1/4.4 | 0.003 | 0.35 |
Phe-Phenylalanine, Leu- Leucine, Gly-Glycine, Asp-Aspartic acid, Ile-Isoleucine, Thr-Threonine, Ser-Serine, Pro-Proline, Ala-Alanine, Ex-Exon, A-Adenine, C-Cytosine, G-Guanine, T-Thymine, LPA-lymphoproliferative assay; SI- stimulation index
P-values ≤0.03 are shown
Values presented as homozygous major allele/heterozygous/homozygous minor allele.
Two degree-of-freedom p-value from analysis of covariance adjusting for age, gender, race, age at first MMR and age at second MMR
Corresponding q-value, based on the concept of false discovery rates. Values can be interpreted as the expected proportion of false positive results among all features at least as extreme as the observed result.