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. Author manuscript; available in PMC: 2008 Aug 7.
Published in final edited form as: Cell Stem Cell. 2008 Feb 7;2(2):183–189. doi: 10.1016/j.stem.2007.11.002

Figure 2.

Figure 2

Transverse section of wild-type (2A) and casper (roy;nacre) eyes (2B) demonstrates that the uniformly pigmented eye in the mutant line is primarily due to a loss of reflective iridophores in the sclera (arrow shows iridophores in wild-type fish), which then exposes the black underlying pigmented retinal epithelium. The remaining eye structures appear intact. Transverse sectioning of the adult skin from wild-type (2C) and casper (2D) shows a thick layer of iridophore crystals in the hypodermis of the wild-type adult (arrow) but a complete loss of this cell layer in the casper skin. Light that would normally be intercepted by epidermal/dermal melanocytes can penetrate deeply into the hypodermis of the mutant, and is not reflected away due to the lack of iridophore crystals. This allows for deep tissue penetration of normal wavelength length. M=muscle layer; D=dermis; Ir=iridophores, C=corneal surface.