Table 1.
Pharmacological specificity of some Avp agonists and antagonists used in behavioral and physiological studies of rats.
| Agent: | Avpr1a | Avpr1b | Avpr2 | Oxtr |
|---|---|---|---|---|
| Avp | s, 1.5 (1) | s, 0.3 (1) | s, 0.5 (1) | s, 1.2 (1) |
| Oxt | s, 78 (2) | s, 250 (2) | s, 370 (2) | s, 1.5 (2) |
| [1-deamino, 8-D]Avp (DDAVP) |
s, 100 (1) | s, 9.3 (3) | s, 0.3 (1) | |
| [d(CH2)51,Tyr(Me)2]Avp (Manning compound) |
i, 0.3 (2) | 313 (4) | s, 65.4 (5) | i, 20 (6) |
| SRX251 | i, 0.66 (7) | |||
| D[Leu4,Lys8]Vp | 3800 (8) | s, 0.16 (8) | 100 (8) | 64 (8) |
| SSR149415 | 1050 (9) | i, 2.5 (9) | 2900 (9) | 270 (9) |
Approximate nM values for KD (Oxt values) or Ki at the specific rat receptor (s=agonist, i=antagonist where known) except for SRX251 (human)
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