Table 3.
Functional divergence estimated in 53 vertebrate bestrophin paralogues
| Comparison | θa | SEb(θ) | LRTc (θ) | Pd | Probability cutoffe |
|---|---|---|---|---|---|
| Best1 vs Best2 | 0.097 | 0.076 | 1.640 | 0.024541 | - |
| Best1 vs Best3 | 0.142 | 0.043 | 10.762 | 0.000488 | - |
| Best1 vs Best4 | 0.217 | 0.039 | 30.099 | 8.88557e-8 | 0.70 |
| Best2 vs Best3 | 0.380 | 0.073 | 27.152 | 6.32074e-9 | 0.80 |
| Best2 vs Best4 | 0.320 | 0.075 | 18.120 | 9.855e-10 | 0.64 |
| Best3 vs Best4 | 0.260 | 0.059 | 19.338 | 9.477e-10 | 0.70 |
a θ is the coefficient of functional divergence.
b SE, standard error.
c LRT (θ) is a likelihood ratio test.
d significance level (Pc) calculated by the method of Fisher's transformation and corrected by Bonferroni.
e Probability cut-off is the minimal posterior probaility for amino acids causing functional divergence.