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. 2008 Apr 14;205(4):751–758. doi: 10.1084/jem.20072182

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Copyright © 2008, The Rockefeller University Press

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Figure 3. — Gene expression profiles and clinical relevance of somatic JAK1 mutations in adult T-ALL. (A) Supervised hierarchical clustering of gene expression profiles performed on blasts from 16 adult T-ALL patients, with (orange) or without (green) a JAK1 mutation. (B) Kaplan-Meier estimates of DFS (top) and OS (bottom) in subjects with (red) or without (black) a JAK mutation. Multivariate analysis confirmed the statistical significance of the reduced DFS and OV among JAK1 mutation-positive patients, and excluded a significant contribution of the more advanced age of these subjects.