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. 2008 Apr 14;205(4):799–810. doi: 10.1084/jem.20071258

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Copyright © 2008, The Rockefeller University Press

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Figure 2. — Anti–IL-23 treatment prevents, but does not reverse, EAU. B10RIII mice were immunized with IRBP peptide (161–180) as indicated. Groups of five mice were treated i.p. with antibodies against p19, p40, or with isotype from the priming (starting day −1) or from the effector phase of EAU induction (starting day 7) every other day, as indicated in Materials and methods. (A) EAU score evaluated in eyes by histopathology 17 d after immunization. (B) DTH responses of mice challenged 48 h earlier. (C) LN proliferation to IRBP peptide 161–180. (D) Cytokine secretion from LN cells stimulated with IRBP peptide 161–180 for 48 h. The data are from a representative experiment of two, with five mice per group. **, P < 0.01; ***, P < 0.001 versus the respective isotype control.