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. 2008 Apr 14;205(4):799–810. doi: 10.1084/jem.20071258

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Copyright © 2008, The Rockefeller University Press

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Figure 7. — Host IL-17 does not seem to play a role in pathogenesis of EAU induced with the Th1 cell line. Two million freshly activated Th1 line cells were infused i.v. into naive B10.RIII Thy1.1 homozygous mice. EAU scores were assessed by fundoscopy. (A) Eyes of recipient mice were removed for isolation of infiltrating cells 10 d after cell transfer. Cells isolated from eyes and incubated with PMA plus ionomycin and brefeldin A (PMA/Io) or with brefeldin A only (unstimulated) were stained for intracellular IFN-γ versus IL-17 and were analyzed by FACS. (B) Recipient mice were treated with neutralizing antibodies to IL-17, IFN-γ, or TNF-α, or with isotype control (0.25 mg/mouse/day, starting day 0). 10 d after transfer, EAU was scored by fundoscopy and confirmed by histopathology. Data show histopathology scores of a representative experiment of three. +, P < 0.05; ++, P < 0.01 versus isotype control; **, P < 0.01 and ***, P < 0.001 versus anti–IL-17.