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. 2008 Apr 14;205(4):799–810. doi: 10.1084/jem.20071258

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Copyright © 2008, The Rockefeller University Press

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Figure 9. — IL-17 KO mice develop EAU and maintain production of proinflammatory cytokines. IL–17 KO mice were immunized with a uveitogenic regimen of IRBP. (A and B) On day 21 after immunization, eyes were collected for EAU evaluation by histopathology (A) and specific DTH responses were recorded as the difference between IRBP- and PBS-injected ears (B). (C and D) LN cells were explanted into culture, and IRBP-specific proliferation (C) and cytokine production (D) were evaluated. The data show averaged responses from 17 animals in three experiments. (E) On day 21 after immunization, eyes were collected and eye-infiltrating cells were extracted and stained for intracellular IFN–γ and IL-17. (F) Ocular extracts prepared as described in Materials and methods were assayed for cytokine levels. (G) Histopathology of EAU in IL-17 KO and WT mice. Bar, 0.25 mm. Data show a representative experiment of three. **, P < 0.01; ***, P < 0.001 versus WT.