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. 2008 Apr 14;205(4):897–913. doi: 10.1084/jem.20071046

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Copyright © 2008, The Rockefeller University Press

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Figure 5. — Overexpression of IL-9 in the intestine induces features of an intestinal anaphylaxis phenotype including mast cell–dependent increased intestinal permeability and intravascular leakage. Transepithelial resistance (A) and intestinal permeability measured by FITC-dextran (B) and horseradish peroxidase (HRP; C) transport in jejunal segments ex vivo for iFABPp-IL-9Tg and BALB/c WT mice, serum mouse mast cell protease-1 and mean number of mast cells per high power field (hpf; D) and intestinal permeability measured by FITC-dextran (E) and HRP (F) transport in jejunal segments ex vivo for iFABPp-IL-9Tg and BALB/c WT mice treated with control or the mast cell stabilizing agent cromolyn sodium. (G) Percentage of hematocrit before and after 4× or 6× i.g. saline or OVA challenges of OVA-sensitized BALB/c WT mice. Percentage of hematocrit in iFABPp-IL-9Tg mice compared with BALB/c WT (H) and Evans blue extravasation in the jejunum and colon of iFABPp-IL-9Tg and BALB/c WT mice (I). (B) Data represents genes found to be up-regulated from profile analysis. (C–G) Data represented as the mean ± the SEM; 4–5 mice per group. (I) Data represents Evans blue concentration in jejunum and colon normalized per milligram of tissue protein. Black line represents mean value in each group.