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. 2008 Apr 14;205(4):897–913. doi: 10.1084/jem.20071046

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Copyright © 2008, The Rockefeller University Press

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Figure 8. — Treatment with mast cell stabilizing agent cromolyn sodium blocks intestinal permeability and protects against antigen sensitization. (A) Experimental regimen. Diarrhea occurrence (B), total serum IgE for iFABPp-IL-9Tg and BALB/c WT mice treated with control or the mast cell stabilizing agent cromolyn sodium and subsequently OVA-challenged mice (C). (D) Passive anaphylaxis (maximum temperature decrease over 20 min) in iFABPp-IL-9Tg mice treated with control or the mast cell stabilizing agent cromolyn sodium. After the 9th OVA i.g. challenge, the mice were i.v. administered IgE-anti-TNP and subsequently i.v. injected withTNP-BSA. (A–D) Data represented as the mean ± the SEM; 4–5 mice per group. (A) Data are represented as the percentage of diarrhea occurrence over the number of OVA challenges in iFABPp-IL-9Tg and BALB/c WT mice treated with control or the mast cell stabilizing agent cromolyn sodium.