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. 2008 Apr 23;3(4):e2025. doi: 10.1371/journal.pone.0002025

Figure 7. An overview of the effects of Lhx2 expression during ES cell differentiation in vitro.

Figure 7

1) Lhx2 expression and simultaneous activation of the c-kit receptor tyrosine kinase and gp130 signal transducer via IL-6 directly induce self-renewal of a distinct multipotential definitive hematopoietic progenitor cell (Def. HPC) present in the EB (1a) leading to the generation of HSC-like cell lines (DoxHPC lines) strictly dependent on Lhx2 expression and SCF/IL-6 for continuous self-renewal in vitro (1b). 2) Lhx2 expression inhibits proliferation of committed primitive erythroid (EryP) precursor cells (2a) and definitive erythroid (EryD) precursor cells (2b). 3) Lhx2 expression interferes with the initial step in ES cell differentiation whereas it does not interfere with the gastrulation process. Mast, mast cells. Mac, macrophages. Neut, neutrophilic granulocyte. Meg, megakaryocytes.