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Shape machine for modeling cell migration. (A) Shape change is driven by the decrease (gray arrowheads pointing inward) or increase (double black arrowheads pointing outward) of the radius at each point along the perimeter. (B) The center of the cell is shifted as a result of the shape change (black arrow). (C) The angle and radius at each perimeter point are then recalculated relative to the new cell center.
