. Author manuscript; available in PMC: 2008 Apr 11.

Published in final edited form as: J Biol Chem. 2005 Apr 13;280(25):23523–23530. doi: 10.1074/jbc.M500894200

Table II. Kinetics of inhibition of fXIa^CD activity by pAB and by fIX.

Kinetics of inhibition were determined from initial velocity measurements using eight concentrations of S2366 or seven concentrations of fIX. Values for K_m and k_cat for cleavage of S2366 were fixed for the purpose of determining K_i in inhibition models. All ranges are ± 2 standard deviations (95% confidence intervals).

Substrate	Inhibitor	Inhibition type	K_m	k_cat	K_i
			μM	s⁻¹	μM
S2366	None		352 ± 42	67 ± 2
S2366	pAB	Competitive	352 ± 42	67 ± 2	38 ± 14
S2366	fIX	No inhibition	352 ± 42	67 ± 2

Table II. Kinetics of inhibition of fXIaCD activity by pAB and by fIX.

Table II. Kinetics of inhibition of fXIa^CD activity by pAB and by fIX.