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. Author manuscript; available in PMC: 2008 Apr 11.
Published in final edited form as: J Biol Chem. 2007 May 31;282(30):21889–21900. doi: 10.1074/jbc.M702841200

FIGURE 7. Effects of GSH or GSSG concentration on mitochondrial ROS production in permeabilized myocytes.

FIGURE 7

GSH/GSSG ratio was varied between 300:1 and 20:1 with either a GSH fixed at 3 mm or with GSSG fixed at 10 μm. Increasing GSSG at a fixed GSH induced corresponding increases in the rate of oxidation of the ROS probe while clamping GSSG to 10 μm inhibited ROS production and shifted mitochondrial ΔΨm depolarization (arrows) to a lower ratio (20:1).