TABLE 1.
Origin, molecular identification, MICs, and MECs of different antifungal against clinical isolates of Aspergillus section Fumigati
| Isolate | Molecular identification
|
MIC (μg/ml)a
|
MEC (μg/ml)b
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Originc | β-Tubulin | Rodlet A | AMB | ITC | VCZ | RVC | POS | TRB | CAS | MICA | |
| ATCC 2004305 | Reference strain | A. fumigatus | A. fumigatus | 0.25-1.0 | 0.125-1.0 | 0.25-1.0 | 0.25-1.0 | 0.03-0.25 | 2.0-8.0 | 0.12-0.5 | 0.03 |
| CNM-CM-1290 | Sputum | A. lentulus | A. lentulus | 4.5 | 9.25 | 4.5 | 3.5 | 0.40 | 1.33 | 0.28 | 0.05 |
| CNM-CM-3134 | Sputum | A. lentulus | A. lentulus | 10 | 10.25 | 6 | 6 | 0.56 | 1.75 | 0.38 | 0.07 |
| CNM-CM-3364 | BAL | A. lentulus | A. lentulus | 8.4 | 8 | 5.6 | 5.6 | 2 | 0.5 | 0.18 | 0.03 |
| CNM-CM-3537 | Sputum | A. lentulus | A. lentulus | 7 | 8.25 | 3.5 | 3 | 0.28 | 1 | 0.42 | 0.04 |
| CNM-CM-3538 | Sputum | A. lentulus | A. lentulus | 7.25 | 8.25 | 7.5 | 7 | 0.75 | 1 | 0.11 | 0.10 |
| CNM-CM-3583 | Sputum | A. lentulus | A. lentulus | 8 | 0.43 | 3.5 | 2 | 0.25 | 1.25 | 1 | 0.03 |
| CNM-CM-3599 | Sputum | A. lentulus | A. lentulus | 2.66 | 0.5 | 4 | 2 | 0.5 | 1 | 0.26 | 0.03 |
| CNM-CM-4330 | Sputum | A. lentulus | A. lentulus | 8 | 6 | 3 | 1.5 | 0.12 | 0.5 | 1.2 | 0.03 |
| CNM-CM-4370 | Sputum | A. lentulus | A. lentulus | 7.33 | 8 | 5.33 | 5.33 | 0.18 | 0.5 | 0.91 | 0.03 |
| CNM-CM-4387 | Sputum | A. lentulus | A. lentulus | 6 | 8 | 4 | 3 | 0.25 | 0.5 | 0.25 | 0.03 |
| CNM-CM-4415 | Sputum | A. lentulus | A. lentulus | 6 | 16 | 5.33 | 4.66 | 0.33 | 0.5 | 0.25 | 0.03 |
| CNM-CM-4420 | Nail | A. lentulus | A. lentulus | 10.66 | 8 | 5.33 | 4 | 0.33 | 1 | 0.33 | 0.03 |
| CNM-CM-4426 | Sputum | A. lentulus | A. lentulus | 12 | 6.66 | 5.33 | 5.33 | 0.20 | 0.83 | 0.22 | 0.03 |
| CNM-CM-4428 | Skin | A. lentulus | A. lentulus | 12 | 7 | 5 | 5 | 0.62 | 0.66 | 0.29 | 0.03 |
| CNM-CM-4063 | BAS | A. fumisynnematus | A. fumisynnematus | 1 | 0.25 | 0.83 | 0.83 | 0.12 | 1.66 | 0.5 | 0.03 |
| CNM-CM-2280 | Sputum | A. fumigatiaffinis | A. fumigatiaffinis | 16 | 6.66 | 6.66 | 6 | 1.16 | 1.66 | 1.3 | 0.04 |
| CNM-CM-3227 | BAL | A. fumigatiaffinis | A. fumigatiaffinis | 8 | 8 | 5.6 | 5 | 0.625 | 1.4 | 0.16 | 0.08 |
| CNM-CM-3303 | Skin | N. hiratsukae | N. hiratsukae | 0.5 | 0.12 | 0.5 | 0.375 | 0.06 | 0.09 | 0.34 | 0.03 |
| CNM-CM-3305 | Skin | N. hiratsukae | N. hiratsukae | 0.31 | 0.185 | 0.375 | 0.25 | 0.045 | 0.06 | 0.03 | 0.14 |
| CNM-CM-3764 | OPE | N. hiratsukae | N. hiratsukae | 1 | 0.33 | 1.66 | 1.33 | 0.16 | 0.25 | 0.26 | 0.04 |
| CNM-CM-3740 | OPE | N. hiratsukae | N. hiratsukae | 0.66 | 0.16 | 1 | 0.66 | 0.10 | 0.20 | 0.66 | 0.03 |
| CNM-CM-4328 | Corneal | N. hiratsukae | N. hiratsukae | 0.75 | 0.25 | 1.25 | 0.5 | 0.09 | 0.09 | 0.03 | 0.03 |
| CNM-CM-3769 | Sputum | N. pseudofischeri | N. pseudofischeri | 1 | 8 | 3.33 | 2 | 0.25 | 1.33 | 0.12 | 0.06 |
| CNM-CM-2270 | Sputum | N. pseudofischeri | N. pseudofischeri | 0.17 | 8 | 3 | 3.5 | 0.31 | 1 | 0.51 | 0.26 |
| CNM-CM-4060 | Sputum | N. pseudofischeri | N. pseudofischeri | 0.25 | 11 | 3.33 | 3.33 | 0.29 | 0.5 | 0.62 | 0.03 |
| CNM-CM-3914 | Nail | N. pseudofischeri | N. pseudofischeri | 0.25 | 16 | 6.66 | 4 | 0.5 | 0.5 | 1 | 0.03 |
| CNM-CM-3147 | OPE | A. viridinutans | A. viridinutans | 0.58 | 14.4 | 4 | 5.66 | 0.41 | 1.2 | 0.67 | 0.20 |
| CNM-CM-4518 | Nail | A. viridinutans | A. viridinutans | 0.37 | 16 | 4 | 4 | 0.25 | 0.75 | 1 | 0.03 |
a
The MICs of amphotericin B (AMB), itraconazole (ITC), voriconazole (VCZ), ravuconazole (RVC), posaconazole (POS), and terbinafine (TRB) are GMs. The MICs for the reference strain are ranges.
b
The MECs of caspofungin (CAS) and micafungin (MICA) are GMs. The CAS MEC for the reference strain is the range.
c
BAL, bronchoalveolar lavage fluid; BAS, bronchoalveolar aspirate; OPE, oropharyngeal exudate.