TABLE 1.
Antifungal properties of DLDa
| Microorganism | MIC (μM)b of:
|
||
|---|---|---|---|
| DLD | Drosomycin | Control peptide | |
| Filamentous fungi | |||
| A. fumigatus | 6.25 | 6.25 | >50 |
| A. nidulans | 6.25 | >50 | >50 |
| A. ustus | 12.5 | 25 | >50 |
| F. solani | 25 | 25 | >50 |
| F. oxysporum | 6.25 | 6.25 | >50 |
| R. oryzae | 6.25 | >50 | >50 |
| Yeasts | |||
| C. albicans | >50 | >50 | >50 |
| C. glabrata | >50 | >50 | >50 |
| C. tropicalis | >50 | >50 | >50 |
| C. krusei | >50 | >50 | >50 |
| C. neoformans | >50 | >50 | >50 |
| Gram-positive bacteria | |||
| S. aureus | >50 | >50 | >50 |
| Streptococcus group A | >50 | >50 | >50 |
| E. faecalis | >50 | >50 | >50 |
| Gram-negative bacteria | |||
| E. coli | >50 | >50 | >50 |
| K. pneumoniae | >50 | >50 | >50 |
| Salmonella serovar Enteritidis | >50 | >50 | >50 |
| P. aeruginosa | >50 | >50 | >50 |
a
Several dilutions of DLD and drosomycin (50 to 0.05 μM) were tested using the liquid growth inhibition assay. An irrelevant peptide was used as a negative control at a concentration of 50 μM, at which no inhibitory effects were apparent.
b
Final concentration.