FIG. 2.
3′ processing and strand transfer activities of recombinant INs. (A) Activities of recombinant INs. INs obtained from patient 3 on day zero (INWT) and at week 14 (INE92Q) were incubated for 1 h at 37°C with 10 nM substrate (21-mer) in the presence of various concentrations of raltegravir (given above the lanes). st., strand; 3′ pro, 3′ processing. (B) Comparison of inhibition curves obtained for isolates from patients 1, 2, and 3. RI, resistance index. Symbols: •, data obtained for wild-type virus at day zero; ▴, data obtained for resistant viruses.