TABLE 1.

CypA PPIase inhibition and activity against HIV-1 replication

Compound	Ki (nM) for CypA PPIase inhibition	IC50 (μM) for HIV-1
		IIIB in MT-4 cellsa	IIIB in PBMCsb	SF2 in PBMCsb
Cs	9.79 ± 1.37	>0.83	0.45	0.54
NIM811	2.11 ± 0.32	0.31 ± 0.11	0.47	0.5
Debio-025	0.34 ± 0.12	0.099 ± 0.063	0.064	0.063
AZT	NDc	0.05 ± 0.01	0.06	0.014

^aThe CPE was determined by MTT staining; values are means±standard deviation from four determinations.

^bAs determined by a p24 ELISA; values are from one determination.

^cND, not determined.