TABLE 2.
Immunosuppressive capacity in vivo
| Treatment | Dose (mg/kg) | IgM level (absorbance)a | Immunological response (% gated cells) after KLH immunization in ratsa
|
||
|---|---|---|---|---|---|
| T lymphocytes | T-helper cells | Cytotoxic T cells | |||
| Vehicle | 0 | 0.87 ± 0.41 | 48.2 ± 5.7 | 30.1 ± 2.7 | 17.2 ± 4.1 |
| Cs | 10 | 0.18 ± 0.09b | 33.6 ± 6.6b | 23.1 ± 5.5 | 9.2 ± 1.3b |
| Debio-025 | 10 | 0.78 ± 0.41 | 52.4 ± 3.3 | 29.8 ± 12.1 | 17.6 ± 3.1 |
| Debio-025 | 25 | 0.78 ± 0.029 | 53.4 ± 5.0 | 34.5 ± 2.9 | 18.0 ± 3.9 |
| Debio-025 | 50 | 0.67 ± 0.41 | 50.0 ± 4.1 | 32.8 ± 5.3 | 16.1 ± 2.7 |
a
The results are mean values±standard deviation.
b
P < 0.01 versus the results for the vehicle control.