TABLE 4.

Efficacy of Debio-025 against multidrug-resistant strains of HIV-1 in PBMCs^a

Virus	Drug resistance phenotype	IC50 (μM)b
HIV-11064-52	APV, ATV, LPV, IDV, NFV, RTV, SQV	0.007 ± 0.001
HIV-1MDR3761	LPV, APV, ATV, IDV, NFV, RTV, SQV, AZT, ddI, 3TC, d4T	0.16 ± 0.14
HIV-1G910-6	ABC, ddC, ddI, TDF, AZT, d4T	0.029 ± 0.029
HIV-1MDR769	APV, ATV, IDV, LPV, NFV, RTV, SQV, 3TC, FTC, ABC, AZT, d4T, ddC, ddI, TDF, EFV, DLV, NVP	0.012 ± 0.006
HIV-1MDR1385	APV, ATV, IDV, LPV, NFV, RTV, SQV, AZT, ddI, 3TC, d4T	0.058 ± 0.023
HIV-152-52	LPV, APV, ATV, IDV, NFV, RTV, SQV	3.12 ± 2.57

^aEfficacy was measured as RT activity.

^bValues are mean ± standard deviation from two independent assays.